A prospective study of depression in French patients with Parkinson's disease. The Depar study
Identifieur interne : 002365 ( Main/Exploration ); précédent : 002364; suivant : 002366A prospective study of depression in French patients with Parkinson's disease. The Depar study
Auteurs : P. Davous [France] ; P. Auquier [France] ; S. Grignon [France] ; H. C. Neukirch [France]Source :
- European Journal of Neurology [ 1351-5101 ] ; 1995-11.
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Abstract
To investigate the prevalence and symptomatology of depression in Parkinson's disease (PD), we have studied 506 unselected patients attending the neurology services in French general hospitals during a 5 month period defined for prospective inclusion. 246 patients (48.6%) were suspected of depression according to different methods of evaluation and 168 (33.2%) were defined as definite or probable depression. According to the Montgomery and Asberg scale, 46 cases (9%) had a severity score suggestive of major depression. As a function of the cut‐off score defined for severity, these patients represented from 23.2 to 43.7% of the depressive population with PD. There was no significant difference between depressed and non depressed PD patients as a function of the patient's current age or age at onset of PD. A significantly higher rate of depression was found among women with PD. A past history of depression was a risk factor for mood disorder after onset of PD. The severely depressed patients had a significantly longer duration of PD and a higher score of cognitive impairment than mildly or moderately depressed and non depressed patients with PD. Depressed patients had a significantly more advanced stage of disability than non‐depressed patients with PD.
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DOI: 10.1111/j.1468-1331.1995.tb00155.x
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According to the Montgomery and Asberg scale, 46 cases (9%) had a severity score suggestive of major depression. As a function of the cut‐off score defined for severity, these patients represented from 23.2 to 43.7% of the depressive population with PD. There was no significant difference between depressed and non depressed PD patients as a function of the patient's current age or age at onset of PD. A significantly higher rate of depression was found among women with PD. A past history of depression was a risk factor for mood disorder after onset of PD. The severely depressed patients had a significantly longer duration of PD and a higher score of cognitive impairment than mildly or moderately depressed and non depressed patients with PD. Depressed patients had a significantly more advanced stage of disability than non‐depressed patients with PD.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Davous, P" sort="Davous, P" uniqKey="Davous P" first="P." last="Davous">P. Davous</name></noRegion><name sortKey="Auquier, P" sort="Auquier, P" uniqKey="Auquier P" first="P." last="Auquier">P. Auquier</name><name sortKey="Auquier, P" sort="Auquier, P" uniqKey="Auquier P" first="P." last="Auquier">P. Auquier</name><name sortKey="Grignon, S" sort="Grignon, S" uniqKey="Grignon S" first="S." last="Grignon">S. Grignon</name><name sortKey="Grignon, S" sort="Grignon, S" uniqKey="Grignon S" first="S." last="Grignon">S. Grignon</name><name sortKey="Neukirch, H C" sort="Neukirch, H C" uniqKey="Neukirch H" first="H. C." last="Neukirch">H. C. Neukirch</name><name sortKey="Neukirch, H C" sort="Neukirch, H C" uniqKey="Neukirch H" first="H. C." last="Neukirch">H. C. Neukirch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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